Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (<i>Lycopersicon esculentum MILL</i>) Grown in Ivory Coast

Dembélé Syndoux; Koffi N’dri Emmanuel; Fofana Ibrahim; Anin Atchibri Anin Louise

doi:doi:10.11648/j.jfns.20231102.13

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Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast

Dembélé Syndoux, Koffi N’dri Emmanuel, Fofana Ibrahim, Anin Atchibri Anin Louise

Published in Journal of Food and Nutrition Sciences (Volume 11, Issue 2)

Received: 21 March 2023 Accepted: 12 April 2023 Published: 27 April 2023

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Abstract

The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.

Published in	Journal of Food and Nutrition Sciences (Volume 11, Issue 2)
DOI	10.11648/j.jfns.20231102.13
Page(s)	43-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Lycopersiconesculentum, Homocysteine, Thromboembolic Diseases, LDL-cholesterol, HDL-cholesterol

References

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Dembélé Syndoux, Koffi N’dri Emmanuel, Fofana Ibrahim, Anin Atchibri Anin Louise. (2023). Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. Journal of Food and Nutrition Sciences, 11(2), 43-52. https://doi.org/10.11648/j.jfns.20231102.13

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ACS Style

Dembélé Syndoux; Koffi N’dri Emmanuel; Fofana Ibrahim; Anin Atchibri Anin Louise. Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. J. Food Nutr. Sci. 2023, 11(2), 43-52. doi: 10.11648/j.jfns.20231102.13

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AMA Style

Dembélé Syndoux, Koffi N’dri Emmanuel, Fofana Ibrahim, Anin Atchibri Anin Louise. Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. J Food Nutr Sci. 2023;11(2):43-52. doi: 10.11648/j.jfns.20231102.13

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@article{10.11648/j.jfns.20231102.13,
  author = {Dembélé Syndoux and Koffi N’dri Emmanuel and Fofana Ibrahim and Anin Atchibri Anin Louise},
  title = {Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {11},
  number = {2},
  pages = {43-52},
  doi = {10.11648/j.jfns.20231102.13},
  url = {https://doi.org/10.11648/j.jfns.20231102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20231102.13},
  abstract = {The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.},
 year = {2023}
}

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TY  - JOUR
T1  - Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast
AU  - Dembélé Syndoux
AU  - Koffi N’dri Emmanuel
AU  - Fofana Ibrahim
AU  - Anin Atchibri Anin Louise
Y1  - 2023/04/27
PY  - 2023
N1  - https://doi.org/10.11648/j.jfns.20231102.13
DO  - 10.11648/j.jfns.20231102.13
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 43
EP  - 52
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20231102.13
AB  - The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.
VL  - 11
IS  - 2
ER  -

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Author Information

Dembélé Syndoux

Training and Research Unit (Faculty) of Agriculture, Fisheries Resources and Agro-food Industry, University of San Pedro, SanPedro, Ivory Coast
Koffi N’dri Emmanuel

Department of Sciences and Technologies, Advanced Teacher's Training College of Abidjan (ENS), Abidjan, Ivory Coast
Fofana Ibrahim

Training and Research Unit (Faculty) of Agriculture, Fisheries Resources and Agro-food Industry, University of San Pedro, SanPedro, Ivory Coast
Anin Atchibri Anin Louise

Laboratory of Nutrition and Food Safety (LNSA), Research Training-Unit of Sciences and Food Technologies, University Nangui Abrogoua, Abidjan, Ivory Coast

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Dembélé Syndoux, Koffi N’dri Emmanuel, Fofana Ibrahim, Anin Atchibri Anin Louise. (2023). Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. Journal of Food and Nutrition Sciences, 11(2), 43-52. https://doi.org/10.11648/j.jfns.20231102.13

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ACS Style

Dembélé Syndoux; Koffi N’dri Emmanuel; Fofana Ibrahim; Anin Atchibri Anin Louise. Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. J. Food Nutr. Sci. 2023, 11(2), 43-52. doi: 10.11648/j.jfns.20231102.13

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AMA Style

Dembélé Syndoux, Koffi N’dri Emmanuel, Fofana Ibrahim, Anin Atchibri Anin Louise. Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast. J Food Nutr Sci. 2023;11(2):43-52. doi: 10.11648/j.jfns.20231102.13

Copy | Download

@article{10.11648/j.jfns.20231102.13,
  author = {Dembélé Syndoux and Koffi N’dri Emmanuel and Fofana Ibrahim and Anin Atchibri Anin Louise},
  title = {Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {11},
  number = {2},
  pages = {43-52},
  doi = {10.11648/j.jfns.20231102.13},
  url = {https://doi.org/10.11648/j.jfns.20231102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20231102.13},
  abstract = {The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Assessment of the Anti-hypertensive and Hyperhomocysteinemic Activity of Aqueous Extracts of Tomato (Lycopersicon esculentum MILL) Grown in Ivory Coast
AU  - Dembélé Syndoux
AU  - Koffi N’dri Emmanuel
AU  - Fofana Ibrahim
AU  - Anin Atchibri Anin Louise
Y1  - 2023/04/27
PY  - 2023
N1  - https://doi.org/10.11648/j.jfns.20231102.13
DO  - 10.11648/j.jfns.20231102.13
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 43
EP  - 52
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20231102.13
AB  - The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. It is one of the most consumed fruits in the world because of its nutritional potential. Indeed, tomato is rich in secondary metabolites and compounds with antioxidant power known for their beneficial effects on health. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1. To do this, rats made hypertensive and hyperhomocysteinemic were treated at a dose of 50 and 100 mg/kg bw for 8 days with the extracts of these tomatoes. At the end of this treatment, the results indicate a decrease in the serum level of LDL-cholesterol and creatinemia respectively of 79.92% and 18.82% in comparison with those of hypertensive rats which did not undergo any treatment. In addition, serum homocysteine level decreased by 35% compared with untreated hyperhomocysteinemic rats. Moreover, a 13.33% increase in serum HDL-cholesterol was observed. In view of the results obtained, regular consumption of tomatoes could help fight against high blood pressure, atherosclerosis, renal failure and prevent cardiovascular complications such as thromboembolic diseases.
VL  - 11
IS  - 2
ER  -

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